Here are San Diego’s best Wellness Retreat Centers! Discover the finest in local design, highlighting their exceptional expertise, creativity, and innovative flair that set them apart. Let’s delve into the best of Wellness excellence in San Diego.

1. Transcendelic

There is no one-size-fits-all approach to healing. That’s why at Transcendelic, we offer a variety of retreats of different types and durations.

At our retreats we offer you a mix of medicine sessions, integration activities and other growth opportunities, and time to play and rest.

Transcendelic offers both psychedelic and psycholytic doses of ketamine, depending on the needs of each retreat participant. Doses of medicine at a psychedelic level are moderate to high, while psycholytic level doses are low to moderate; both have different advantages. We will work with you to individualize your dose for each medicine session so you will have the experience that is best suited for your needs.

Benefits of a Retreat Setting

Our retreat approach allows for connection to Earth and to others, and facilitates profound experiences that would otherwise be lost and even impossible in a typical clinical setting. Retreats offer a natural separation from the usual routines and patterns of daily life, and this change of surroundings allows for greater focus on oneself. The serene beauty of our locations further enhances positive mindsets before, during, and after the psychedelic experiences.

Currently, our retreats in California are among the few options worldwide for individuals seeking a legal and therapeutically-supported environment to experience psychedelics. We are able to offer a variety of holistic treatment modalities to ensure proper care of the body, mind, and spirit.

2. Cove Wellness Detox Spa of La Jolla

Experience this hidden treasure just steps from the Pacific Ocean
Cove Wellness is located in the seaside village of La Jolla, California. The serenity of this world-renowned cove creates an ideal setting to renew your energy and recharge your spirit.

Since 1993 this specialty spa for men and women have been enhancing the health and beauty of it’s clients with a unique and effective synergy of lymphatic services.

Body Care
The Importance of Prevention
Purifying Wellness Therapies can set the precondition for the body to heal itself and are a true path to vitality, healthy weight loss and radiant beauty. A whole body approach to wellness, prevention and healthy aging.

Cove Wellness’ premise is that illness is easier to prevent than it is to cure.
Cove Wellness offers purifying treatments that can set the precondition for self healing and non invasive body care alternatives for radiant beauty naturally. Educating and inspiring healthy lifestyle choices and self care are our priority.

Over time, many of us have come to accept developing a degenerative disease or simply feeling incrementally worse each year as part of the aging process. Integrating prevention into our lifestyles may require seismic shifts in our perception of wellness and the stewardship of our own bodies.

3. The Sanctuary Wellness Experience San Diego

Reset Your Mind
Just like our digital devices, humans need to be reset…but life’s fast pace doesn’t make it easy to pause. We’re constantly connected to our phones and computers and we never truly unwind. That’s exactly why we created The Sanctuary Wellness Retreats.

Refresh Your Body
Deep down, we know what our bodies need. We need clean, biodynamic food, cellular hydration, balanced minerals, intuitive movement, well dosed sun light, grounding, creative playtime, deep soul connection and of course restorative sleep.

Rediscover Your Spirit
Our spirit needs to be nurtured equally along with our body. The demands of a crazy world don’t give us time to balance our mind, body and spirit so we’re grounded and connected to what matters most. When is the last time you journaled? Or painted? Danced? or Laughed? We offer opportunities to unlock your creative spirit again.

4. Sojourn Healing Collective San Diego

WE BELIEVE HEALING IS A PRACTICE
Our community values restoration and grounded somatic movement to support the deep work that happens inside our walls. We offer yoga, meditation, breathwork, sound healing and trainings across a wide variety of spiritual modalities. You’ll find an abundance of opportunities to release, grow and integrate.

We believe healing is the sustained practice of self study and the foundation of your most embodied expansion. Our offerings are an ongoing invitation to begin again.

At Sojourn, we tend to the health of your nervous system through the vehicles of body, mind, and breath.

Daily classes offer space for sustained practice and help you to move through life with more awareness, embodiment, and ease.

Retreats, spiritual workshops, trainings, and other group healing experiences are an invitation to travel deeper into your body and your life.

5. Santa Maria Health Resort & Longevity Retreat

Our journey to Santa Maria was a deeply personal path of healing from chronic Lyme disease. It led us through more than 40 clinics, medical resorts, and doctors across the U.S., Germany, Switzerland, and Russia, as well as numerous international conferences. Along the way, we tried the Western methods (prolonged courses of antibiotics) and nearly every integrative care procedure available—from the whole-body hyperthermia to photodynamic laser protocols,electromagnetic field therapy (PEMF), intravenous ozone therapy , and stem cells. We met fellow patients experiencing both mild and severe chronic symptoms, many of whom had been misdiagnosed.
Yuri, a distinguished life scientist, meticulously studied peer-reviewed research on each treatment method and its potential combinations. This wealth of experience and knowledge is what we are excited to share with Santa Maria’s guests.

Most importantly, we came to a profound realization: there is no such thing as isolated conditions like «knee arthritis,» «chronic headaches,» «low thyroid hormone,» or «bad teeth.» The human body is an incredibly complex supersystem, composed of more than 100 trillion cells (along with ten times that number in microbial organisms), all interconnected by over 90,000 miles of electrical pathways within the nervous system. Every cell, tissue, and organ is linked to the rest of the body through biochemical, thermodynamic, and quantum processes. Therefore, any localized symptom is merely a reflection of a larger systemic imbalance—meaning true healing requires addressing the body and mind as a whole.
This holistic principle is best embodied in the concept of P4 Medicine, an advanced healthcare model based on four key pillars: Predictive, Preventive, Personalized, and Participatory. Unlike conventional Western medicine, which primarily focuses on treating acute conditions with pharmaceuticals and interventions, the P4 model emphasizes early detection, root-cause treatment, and lifelong strategies for disease prevention and longevity.
P4 Medicine integrates comprehensive functional diagnostics, personalized treatment programs, and long-term health support plans for every patient. This is the model we implement at Santa Maria.

View of the main hall of the Santa Maria clinic from above
Santa Maria Team
Although relatively new in the U.S., the P4 approach has been successfully practiced in European medical resorts for years. These integrative healthcare centers are renowned for their exceptional preventive care and long-lasting effects on chronic conditions. By combining cutting-edge holistic therapies, restorative treatments, IV infusions, and clinical-grade nutrition, these resorts create customized health programs that promote deep healing. Their effectiveness is further enhanced by educational workshops, nutrition master classes and physical activities. Unsurprisingly, many guests return year after year, choosing to invest in proactive wellness rather than costly hospital treatments. Studies suggest that regular preventive care in such medical resorts is one of the key reasons why Europeans live three to seven years longer than Americans.

At Santa Maria, we have adapted this successful model to fit the unique challenges of the U.S. healthcare system, as well as the evolving landscape of remote work and the gig economy. We have carefully selected the most effective treatments for health restoration, relaxation, and chronic condition relief, creating high-impact programs designed by a leading preventive care doctor in Russia. Additionally, we offer customized à la carte treatment packages, allowing each guest to tailor their experience to their specific health needs.